Viral haemorrhagic fever (VHF)

Pathogens

All ss RNA virus

  • Ebola (Philo): incubation 3-21 days

  • Marburg (Philo):

  • Crimea Congo

  • Lassa

  • Clinical

  • Sudden onset

  • Lassa

Diagnosis

  • Nucleic acid detection: RT-PCR, RT-LAMP, Recombinase polymerase amplification (RPA), Next Generation Sequencing (NGS) e.g. MinION

Treatment

  • Filovirus: Ebola (Inmazeb, Ebanga, Ervebo), Marburg

  • Arenavirus (Lassa: ribavirin (Rib), Junin (Junin Candid #1 vaccine strain), Machupo (nil)