Cryptococcus

  • Cryptococcus neoformans

  • India Ink

  • Cryptococcal antigen (CrAg)

Treatment (meningitis)

  • Amphotericin B & Flucytosine for 2 weeks; Fluconazole 400mg for 8-10 weeks; fluconazole 200mg until CD4>100 & HIV-VL supressed

  • Headache: LPs (painkillers not helpful)

  • ART after 4 weeks (avoid too early because of IRIS)

References

Vietnam case, May 31 2021

Disseminated Cryptococcosis (NEJM, 2021)